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(A) Results of screening the antibacterial compounds library (containing 1,128 bioactive antibacterial agents), at a fixed concentration of 1 μM, against N. gonorrhoeae FA1090. Drugs exhibiting ≥ 90% inhibition of bacterial growth were considered positive hits (red). (B) Schematic of the screening process in this study, and the number of test agents at each step to finally obtain two molecules that are potent against N. gonorrhoeae and C. <t>trachomatis</t> .
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(A) Results of screening the antibacterial compounds library (containing 1,128 bioactive antibacterial agents), at a fixed concentration of 1 μM, against N. gonorrhoeae FA1090. Drugs exhibiting ≥ 90% inhibition of bacterial growth were considered positive hits (red). (B) Schematic of the screening process in this study, and the number of test agents at each step to finally obtain two molecules that are potent against N. gonorrhoeae and C. <t>trachomatis</t> .
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(A) Results of screening the antibacterial compounds library (containing 1,128 bioactive antibacterial agents), at a fixed concentration of 1 μM, against N. gonorrhoeae FA1090. Drugs exhibiting ≥ 90% inhibition of bacterial growth were considered positive hits (red). (B) Schematic of the screening process in this study, and the number of test agents at each step to finally obtain two molecules that are potent against N. gonorrhoeae and C. trachomatis .

Journal: PLOS One

Article Title: Screening a library of antibacterial compounds leads to discovery of novel inhibitors for Neisseria gonorrhoeae and Chlamydia trachomatis

doi: 10.1371/journal.pone.0340486

Figure Lengend Snippet: (A) Results of screening the antibacterial compounds library (containing 1,128 bioactive antibacterial agents), at a fixed concentration of 1 μM, against N. gonorrhoeae FA1090. Drugs exhibiting ≥ 90% inhibition of bacterial growth were considered positive hits (red). (B) Schematic of the screening process in this study, and the number of test agents at each step to finally obtain two molecules that are potent against N. gonorrhoeae and C. trachomatis .

Article Snippet: N. gonorrhoeae FA1090, C. trachomatis serovar L2 (ATCC VR-902B), and McCoy cell line were purchased from the American Type Culture Collection (ATCC).

Techniques: Concentration Assay, Inhibition